The mechanism by which AVH occurs spontaneously from the brain’s intrinsic activity is of great clinical interest. Since the neurobiological mechanisms involved in AVH remain unclear insights into the pathophysiology of AVH could facilitate the development of novel strategies to treat patients who do not respond to currently used medications. Clinical options to treat such patients are currently limited. In 30% of patients with AVH, the hallucinations are not affected by clinical treatments ( 3), and cause functional disability and therefore lower quality of life. The prevalence of AVH exceeds 60% in patients with schizophrenia worldwide ( 1, 2). Correlation analysis showed that the normalized GC ratios from the left STG to Broca’s area, from the left STG to the right homolog of Broca’s area, and from the right STG to the right homolog of Broca’s area were negatively correlated with severity of AVH, and the normalized GC ratios from Broca’s area to the left hippocampus and from Broca’s area to the right STG were positively correlated with severity of AVH.Ĭonclusion: Our findings indicate a causal influence of pivotal regions involving the auditory, language, and memory networks in schizophrenia with AVH, which provide a deeper understanding of the neural mechanisms underlying AVH.Īuditory verbal hallucinations (AVH) are the most prominent and burdensome symptoms of schizophrenia, and comprise sensory experiences wherein voices are heard without a causative external stimulus. Results: Granger causality (GC) increased from Broca’s area to the left STG, and decreased from the right homolog of Wernicke’s area to the right homolog of Broca’s area, and from the right STG to the right hippocampus in the AVH group compared with the non-AVH group. The bilateral superior temporal gyrus (STG), Broca’s area, Wernicke’s area, putamen, and hippocampus were selected as regions of interest. Patients and Methods: Eighteen patients with schizophrenia with AVH and eighteen matched patients without AVH who received resting-state fMRI scans were enrolled in the study.
In this study, we aimed to elucidate causal influences related to AVH in key regions of auditory, language, and memory networks, by using Granger causality analysis (GCA). Although abnormal functional connectivity associated with AVH has been reported in multiple regions, the changes in information flow remain unclear.
Purpose: Auditory verbal hallucinations (AVH) are among the most common and prominent symptoms of schizophrenia. 3Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China.2Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China.1Department of MRI, Shaanxi Provincial People’s Hospital, Xi’an, China.Jie Gao 1†, Dongsheng Zhang 1†, Lei Wang 2, Wei Wang 3, Yajuan Fan 3, Min Tang 1, Xin Zhang 1, Xiaoyan Lei 1, Yarong Wang 2, Jian Yang 2* and Xiaoling Zhang 1*
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